Assay Detail
Functional
CHEMBL4821252
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HT-1080 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New bioactive 5-arylcarboximidamidopyrazolo[3,4-c]pyridines: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.26 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 8.10 |
| CHEMBL4855241 | — | — | 1 | 6.19 |
| CHEMBL4868398 | — | — | 1 | 6.19 |
| CHEMBL4872148 | — | — | 1 | 6.16 |
| CHEMBL4858165 | — | — | 1 | 6.07 |
| CHEMBL4875721 | — | — | 1 | 5.96 |
| CHEMBL4859464 | — | — | 1 | 5.95 |
| CHEMBL4853942 | — | — | 1 | 5.92 |
| CHEMBL4876831 | — | — | 1 | 5.85 |
| CHEMBL4874473 | — | — | 1 | 5.50 |
| CHEMBL4861636 | — | — | 1 | 5.47 |
| CHEMBL4847387 | — | — | 1 | 5.47 |
| CHEMBL4877558 | — | — | 1 | 5.41 |
| CHEMBL4858803 | — | — | 1 | 5.33 |
| CHEMBL4871022 | — | — | 1 | 5.32 |
| CHEMBL4874162 | — | — | 1 | 5.28 |
| CHEMBL4864284 | — | — | 1 | 5.25 |
| CHEMBL4854290 | — | — | 1 | 5.21 |
| CHEMBL4848047 | — | — | 1 | 5.17 |
| CHEMBL4863630 | — | — | 1 | 5.17 |
| CHEMBL4876818 | — | — | 1 | 4.96 |
| CHEMBL4862061 | — | — | 1 | 4.94 |
| CHEMBL4857600 | — | — | 1 | 4.89 |
| CHEMBL4863465 | — | — | 1 | 4.76 |
| CHEMBL4850176 | — | — | 1 | 4.75 |
| CHEMBL4847359 | — | — | 1 | 4.68 |
| CHEMBL4872448 | — | — | 1 | 4.67 |
| CHEMBL4871686 | — | — | 1 | 4.66 |
| CHEMBL4875480 | — | — | 1 | 4.62 |
| CHEMBL4873091 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4855241 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4868398 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4872148 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4858165 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4875721 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4859464 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4853942 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4876831 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4874473 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4861636 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4847387 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4877558 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4858803 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4871022 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4874162 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4864284 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4854290 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4848047 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4863630 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4876818 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL4862061 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4857600 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4863465 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL4850176 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4847359 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4872448 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL4871686 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4875480 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4873091 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL4872036 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL4867771 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL4877847 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL4851747 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL4860843 | — | IC50 | = | 36500.0 | nM | 4.44 |
| CHEMBL4868960 | — | IC50 | = | 46700.0 | nM | 4.33 |
| CHEMBL4858993 | — | IC50 | - | — | - | |
| CHEMBL4878742 | — | IC50 | - | — | - | |
| CHEMBL4868253 | — | IC50 | - | — | - | |
| CHEMBL4854754 | — | IC50 | - | — | - | |
| CHEMBL4856698 | — | IC50 | - | — | - | |
| CHEMBL4869504 | — | IC50 | - | — | - | |
| CHEMBL4865304 | — | IC50 | - | — | - |