Assay Detail
Binding
CHEMBL4821401
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Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.25 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4847987 | — | — | 1 | 6.32 |
| CHEMBL4854298 | — | — | 1 | 6.12 |
| CHEMBL4868014 | — | — | 1 | 5.87 |
| CHEMBL4858186 | — | — | 1 | 5.57 |
| CHEMBL4853742 | — | — | 1 | 5.49 |
| CHEMBL4856140 | — | — | 1 | 5.42 |
| CHEMBL4855755 | — | — | 1 | 5.33 |
| CHEMBL4849361 | — | — | 1 | 5.13 |
| CHEMBL4849436 | — | — | 1 | 4.70 |
| CHEMBL4855838 | — | — | 1 | 4.68 |
| CHEMBL4868687 | — | — | 1 | 4.55 |
| CHEMBL4853637 | — | — | 1 | 4.52 |
| CHEMBL4872772 | — | — | 1 | 4.52 |
| CHEMBL153 | TROLOX | — | 1 | - |
| CHEMBL196 | ASCORBIC ACID | 4.0 | 1 | - |
| CHEMBL280998 | CATECHOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4847987 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL4854298 | — | IC50 | = | 759.0 | nM | 6.12 |
| CHEMBL4868014 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4858186 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL4853742 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL4856140 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL4855755 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL4849361 | — | IC50 | = | 7320.0 | nM | 5.13 |
| CHEMBL4849436 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL4855838 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL4868687 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL4853637 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL4872772 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL153 | TROLOX | IC50 | - | — | - | |
| CHEMBL196 | ASCORBIC ACID | IC50 | - | — | - | |
| CHEMBL280998 | CATECHOL | IC50 | - | — | - |