Assay Detail
Binding
CHEMBL4821415
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Inhibition of human recombinant CES2 expressed in mouse NSO cells using 4-NPA as substrate by spectrophotometric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NSO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.37 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854298 | — | — | 1 | 8.39 |
| CHEMBL4853742 | — | — | 1 | 8.36 |
| CHEMBL4858186 | — | — | 1 | 8.01 |
| CHEMBL4868014 | — | — | 1 | 7.97 |
| CHEMBL4855838 | — | — | 1 | 7.77 |
| CHEMBL4853637 | — | — | 1 | 7.63 |
| CHEMBL4849436 | — | — | 1 | 7.32 |
| CHEMBL4855755 | — | — | 1 | 7.15 |
| CHEMBL4849361 | — | — | 1 | 7.14 |
| CHEMBL4868687 | — | — | 1 | 6.71 |
| CHEMBL4849604 | — | — | 1 | 6.64 |
| CHEMBL4872772 | — | — | 1 | 6.47 |
| CHEMBL4853013 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854298 | — | IC50 | = | 4.04 | nM | 8.39 |
| CHEMBL4853742 | — | IC50 | = | 4.33 | nM | 8.36 |
| CHEMBL4858186 | — | IC50 | = | 9.84 | nM | 8.01 |
| CHEMBL4868014 | — | IC50 | = | 10.81 | nM | 7.97 |
| CHEMBL4855838 | — | IC50 | = | 16.92 | nM | 7.77 |
| CHEMBL4853637 | — | IC50 | = | 23.44 | nM | 7.63 |
| CHEMBL4849436 | — | IC50 | = | 47.74 | nM | 7.32 |
| CHEMBL4855755 | — | IC50 | = | 70.51 | nM | 7.15 |
| CHEMBL4849361 | — | IC50 | = | 72.31 | nM | 7.14 |
| CHEMBL4868687 | — | IC50 | = | 193.34 | nM | 6.71 |
| CHEMBL4849604 | — | IC50 | = | 230.09 | nM | 6.64 |
| CHEMBL4872772 | — | IC50 | = | 339.25 | nM | 6.47 |
| CHEMBL4853013 | — | IC50 | = | 610.24 | nM | 6.21 |