Assay Detail
Binding
CHEMBL4822006
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New tetrahydroisoquinoline-based D<sub>3</sub>R ligands with an o-xylenyl linker motif.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.97 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1255588 | — | — | 1 | 8.55 |
| CHEMBL4878587 | — | — | 1 | 7.24 |
| CHEMBL4876260 | — | — | 1 | 7.04 |
| CHEMBL4846574 | — | — | 1 | 6.29 |
| CHEMBL4855891 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1255588 | — | Ki | = | 2.84 | nM | 8.55 |
| CHEMBL4878587 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL4876260 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL4846574 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL4855891 | — | Ki | = | 1970.0 | nM | 5.71 |