Assay Detail
Binding
CHEMBL4822011
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Displacement of [3H]DTG from sigma2 receptor(unknown origin)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New tetrahydroisoquinoline-based D<sub>3</sub>R ligands with an o-xylenyl linker motif.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.72 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | 2.0 | 1 | 8.14 |
| CHEMBL291439 | — | — | 1 | 7.99 |
| CHEMBL4878121 | — | — | 1 | 6.85 |
| CHEMBL4854512 | — | — | 1 | 6.62 |
| CHEMBL4290759 | — | — | 1 | 6.57 |
| CHEMBL4876926 | — | — | 1 | 6.54 |
| CHEMBL4856161 | — | — | 1 | 6.44 |
| CHEMBL4863748 | — | — | 1 | 6.36 |
| CHEMBL4862839 | — | — | 1 | 6.32 |
| CHEMBL4867331 | — | — | 1 | 6.21 |
| CHEMBL4857166 | — | — | 1 | 5.85 |
| CHEMBL4877460 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | Ki | = | 7.21 | nM | 8.14 |
| CHEMBL291439 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL4878121 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4854512 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL4290759 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL4876926 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL4856161 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL4863748 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL4862839 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL4867331 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL4857166 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL4877460 | — | Ki | > | 10000.0 | nM | - |