Assay Detail
Binding
CHEMBL4822083
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Binding affinity to P38alpha MAPK (unknown origin) using Smad3 as substrate incubated for 1 hr in presence of ATP by ELISA based competitive binding potency assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of an allosteric and Smad3-selective inhibitor of p38αMAPK using a substrate-based approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.76 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4868525 | — | — | 1 | 8.89 |
| CHEMBL278041 | SB-202190 | — | 1 | 7.96 |
| CHEMBL4852110 | — | — | 1 | 6.54 |
| CHEMBL4847239 | — | — | 1 | 6.52 |
| CHEMBL4870695 | — | — | 1 | 5.58 |
| CHEMBL4858673 | — | — | 1 | 5.05 |
| CHEMBL4850724 | — | — | 1 | - |
| CHEMBL4861772 | — | — | 1 | - |
| CHEMBL4860774 | — | — | 1 | - |
| CHEMBL4864686 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4868525 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL278041 | SB-202190 | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4852110 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4847239 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4870695 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4858673 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4850724 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4861772 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4860774 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4864686 | — | IC50 | > | 1000.0 | nM | - |