Assay Detail
Functional
CHEMBL4822096
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Inhibition of LPS-induced 15(S)-HETE production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by ELISA
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.43 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4867950 | — | — | 1 | 6.77 |
| CHEMBL4862415 | — | — | 1 | 6.38 |
| CHEMBL4876637 | — | — | 1 | 5.84 |
| CHEMBL4852008 | — | — | 1 | 5.69 |
| CHEMBL4853361 | — | — | 1 | 5.44 |
| CHEMBL4861765 | — | — | 1 | 5.41 |
| CHEMBL4862389 | — | — | 1 | 5.15 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.13 |
| CHEMBL4872636 | — | — | 1 | 5.05 |
| CHEMBL1034 | DICLOFENAC SODIUM | 4.0 | 1 | 4.91 |
| CHEMBL4869763 | — | — | 1 | 4.73 |
| CHEMBL4857790 | — | — | 1 | 4.67 |
| CHEMBL4847404 | — | — | 1 | - |
| CHEMBL4856646 | — | — | 1 | - |
| CHEMBL4876862 | — | — | 1 | - |
| CHEMBL4876293 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4867950 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4862415 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4876637 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4852008 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL4853361 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4861765 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL4862389 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL118 | CELECOXIB | IC50 | = | 7460.0 | nM | 5.13 |
| CHEMBL4872636 | — | IC50 | = | 8860.0 | nM | 5.05 |
| CHEMBL1034 | DICLOFENAC SODIUM | IC50 | = | 12190.0 | nM | 4.91 |
| CHEMBL4869763 | — | IC50 | = | 18550.0 | nM | 4.73 |
| CHEMBL4857790 | — | IC50 | = | 21260.0 | nM | 4.67 |
| CHEMBL4847404 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4856646 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4876862 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4876293 | — | IC50 | > | 50000.0 | nM | - |