Assay Detail
Binding
CHEMBL4822204
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Binding affinity to human recombinant TET2 (1099 to 1936) catalytic domain assessed as dissociation constant by micro-scale thermophoresis analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR insights into TET2 catalytic domain inhibition: Synthesis of 2-Hydroxy-4-Methylene-pentanedicarboxylates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.97 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4851104 | — | — | 1 | 6.52 |
| CHEMBL4855677 | — | — | 1 | 6.21 |
| CHEMBL4859276 | — | — | 1 | 5.69 |
| CHEMBL4870693 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4851104 | — | Kd | = | 300.0 | nM | 6.52 |
| CHEMBL4855677 | — | Kd | = | 610.0 | nM | 6.21 |
| CHEMBL4859276 | — | Kd | = | 2050.0 | nM | 5.69 |
| CHEMBL4870693 | — | Kd | = | 3420.0 | nM | 5.47 |