Assay Detail
Functional
CHEMBL4822357
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Antimalarial activity against Plasmodium falciparum RKL9 infected in human RBC assessed as reduction in parasite growth incubated for 24 hrs by giemsa staining based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | RBC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.32 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3885085 | — | — | 1 | 7.40 |
| CHEMBL3211519 | — | — | 1 | 7.38 |
| CHEMBL3198390 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3885085 | — | IC50 | = | 40.2 | nM | 7.40 |
| CHEMBL3211519 | — | IC50 | = | 42.2 | nM | 7.38 |
| CHEMBL3198390 | — | IC50 | = | 66.0 | nM | 7.18 |