Assay Detail
Binding
CHEMBL4822376
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Inhibition of human CA1 by stopped-flow assay
33
Total Activities
24
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Developments of small molecules as inhibitors for carbonic anhydrase isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.80 | 8.42 |
| Ki | 16 | 7.31 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4857592 | — | — | 2 | 8.48 |
| CHEMBL4869398 | — | — | 2 | 8.48 |
| CHEMBL4847613 | — | — | 2 | 8.45 |
| CHEMBL4849196 | — | — | 2 | 8.42 |
| CHEMBL4876038 | — | — | 2 | 8.42 |
| CHEMBL4864555 | — | — | 2 | 8.39 |
| CHEMBL4847624 | — | — | 2 | 8.38 |
| CHEMBL4872387 | — | — | 2 | 8.38 |
| CHEMBL4872231 | — | — | 1 | 7.02 |
| CHEMBL4868330 | — | — | 1 | 7.01 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 2 | 6.74 |
| CHEMBL4861966 | — | — | 1 | 6.16 |
| CHEMBL4863113 | — | — | 1 | 5.75 |
| CHEMBL4849396 | — | — | 1 | 5.64 |
| CHEMBL4876347 | — | — | 1 | 5.60 |
| CHEMBL4865818 | — | — | 1 | 5.44 |
| CHEMBL4873049 | — | — | 1 | 5.30 |
| CHEMBL4863803 | — | — | 1 | 5.23 |
| CHEMBL4854006 | — | — | 1 | 5.16 |
| CHEMBL4878381 | — | — | 1 | 5.09 |
| CHEMBL4863999 | — | — | 1 | 5.00 |
| CHEMBL4849226 | — | — | 1 | 4.92 |
| CHEMBL4864797 | — | — | 1 | 4.34 |
| CHEMBL4873646 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4869398 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL4857592 | — | Ki | = | 3.33 | nM | 8.48 |
| CHEMBL4847613 | — | Ki | = | 3.53 | nM | 8.45 |
| CHEMBL4869398 | — | IC50 | = | 3.77 | nM | 8.42 |
| CHEMBL4849196 | — | Ki | = | 3.83 | nM | 8.42 |
| CHEMBL4876038 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL4849196 | — | IC50 | = | 3.92 | nM | 8.41 |
| CHEMBL4864555 | — | Ki | = | 4.08 | nM | 8.39 |
| CHEMBL4847613 | — | IC50 | = | 4.05 | nM | 8.39 |
| CHEMBL4847624 | — | IC50 | = | 4.18 | nM | 8.38 |
| CHEMBL4864555 | — | IC50 | = | 4.19 | nM | 8.38 |
| CHEMBL4872387 | — | IC50 | = | 4.12 | nM | 8.38 |
| CHEMBL4876038 | — | IC50 | = | 4.13 | nM | 8.38 |
| CHEMBL4857592 | — | IC50 | = | 4.24 | nM | 8.37 |
| CHEMBL4872387 | — | Ki | = | 5.26 | nM | 8.28 |
| CHEMBL4847624 | — | Ki | = | 5.95 | nM | 8.22 |
| CHEMBL4872231 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL4868330 | — | Ki | = | 96.6 | nM | 7.01 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 182.09 | nM | 6.74 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 197.1 | nM | 6.71 |
| CHEMBL4861966 | — | Ki | = | 692.0 | nM | 6.16 |
| CHEMBL4863113 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4849396 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4876347 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4865818 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4873049 | — | Ki | = | 5021.1 | nM | 5.30 |
| CHEMBL4863803 | — | Ki | = | 5867.4 | nM | 5.23 |
| CHEMBL4854006 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4878381 | — | Ki | = | 8169.6 | nM | 5.09 |
| CHEMBL4863999 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4849226 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4864797 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4873646 | — | Ki | > | 10000.0 | nM | - |