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Assay Detail

CHEMBL4822422

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Functional
Cytotoxicity against human U-251 cells by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-251
Confidence 1 — Organism
Curated By Autocuration

Target

U-251 (CHEMBL615022)
Type CELL-LINE
Organism Homo sapiens

Publication

Chemical modifications of ergostane-type triterpenoids from Antrodia camphorata and their cytotoxic activities.
Li B, Kuang Y, Yi Y, Qiao X, Liang L, Ye M.
Bioorg Med Chem Lett (2021) 43 : 128066 -128066
PubMed 33915258 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.66 5.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4853017 1 5.54
CHEMBL4848965 1 5.48
CHEMBL4857161 1 4.98
CHEMBL4846052 1 4.77
CHEMBL4875885 1 4.56
CHEMBL810 TEMOZOLOMIDE 4.0 1 4.44
CHEMBL4867882 1 4.08
CHEMBL4865243 1 4.03
CHEMBL4854932 1 4.02
CHEMBL4863216 1 -
CHEMBL4862316 1 -
CHEMBL428647 PACLITAXEL 4.0 1 -
CHEMBL481 IRINOTECAN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4853017 IC50 = 2900.0 nM 5.54
CHEMBL4848965 IC50 = 3300.0 nM 5.48
CHEMBL4857161 IC50 = 10400.0 nM 4.98
CHEMBL4846052 IC50 = 17100.0 nM 4.77
CHEMBL4875885 IC50 = 27400.0 nM 4.56
CHEMBL810 TEMOZOLOMIDE IC50 = 36400.0 nM 4.44
CHEMBL4867882 IC50 = 82400.0 nM 4.08
CHEMBL4865243 IC50 = 93200.0 nM 4.03
CHEMBL4854932 IC50 = 95800.0 nM 4.02
CHEMBL4863216 IC50 > 100000.0 nM -
CHEMBL4862316 IC50 > 100000.0 nM -
CHEMBL428647 PACLITAXEL IC50 - -
CHEMBL481 IRINOTECAN IC50 - -