Assay Detail
Binding
CHEMBL4822734
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human wild type RIPK3 (M1 to Q307) expressed in bacterial system by kinomescan assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 3 (CHEMBL1795199) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Enantiomeric profiling of a chiral benzothiazole necroptosis inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.74 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4540715 | — | — | 1 | 7.11 |
| CHEMBL3125890 | — | — | 1 | 6.98 |
| CHEMBL4850219 | — | — | 1 | 6.84 |
| CHEMBL4860842 | — | — | 1 | 6.57 |
| CHEMBL4869920 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4540715 | — | Kd | = | 77.0 | nM | 7.11 |
| CHEMBL3125890 | — | Kd | = | 105.0 | nM | 6.98 |
| CHEMBL4850219 | — | Kd | = | 145.0 | nM | 6.84 |
| CHEMBL4860842 | — | Kd | = | 270.0 | nM | 6.57 |
| CHEMBL4869920 | — | Kd | = | 650.0 | nM | 6.19 |