Assay Detail
Binding
CHEMBL4822803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human ERbeta LBD assessed as inhibition constant measured after 2 hrs by microplate reader
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel hybrid conjugates with dual estrogen receptor α degradation and histone deacetylase inhibitory activities for breast cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.94 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4853580 | — | — | 1 | 7.25 |
| CHEMBL3589353 | — | — | 1 | 7.15 |
| CHEMBL4851145 | — | — | 1 | 6.99 |
| CHEMBL3589367 | — | — | 1 | 6.96 |
| CHEMBL4849503 | — | — | 1 | 6.46 |
| CHEMBL4849015 | — | — | 1 | 6.34 |
| CHEMBL4875988 | — | — | 1 | 5.88 |
| CHEMBL4862733 | — | — | 1 | 5.81 |
| CHEMBL4878251 | — | — | 1 | 5.75 |
| CHEMBL4873312 | — | — | 1 | 5.70 |
| CHEMBL4869562 | — | — | 1 | 5.67 |
| CHEMBL4859208 | — | — | 1 | 5.62 |
| CHEMBL4870760 | — | — | 1 | 5.58 |
| CHEMBL4852827 | — | — | 1 | 5.55 |
| CHEMBL4853571 | — | — | 1 | 5.55 |
| CHEMBL4851237 | — | — | 1 | 5.55 |
| CHEMBL4870293 | — | — | 1 | 5.55 |
| CHEMBL4861959 | — | — | 1 | 5.51 |
| CHEMBL4869951 | — | — | 1 | 5.51 |
| CHEMBL4874242 | — | — | 1 | 5.47 |
| CHEMBL4871032 | — | — | 1 | 5.47 |
| CHEMBL4874175 | — | — | 1 | 5.31 |
| CHEMBL4862515 | — | — | 1 | - |
| CHEMBL4855745 | — | — | 1 | - |
| CHEMBL4868001 | — | — | 1 | - |
| CHEMBL4855392 | — | — | 1 | - |
| CHEMBL4855191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4853580 | — | Ki | = | 56.67 | nM | 7.25 |
| CHEMBL3589353 | — | Ki | = | 71.19 | nM | 7.15 |
| CHEMBL4851145 | — | Ki | = | 101.79 | nM | 6.99 |
| CHEMBL3589367 | — | Ki | = | 108.58 | nM | 6.96 |
| CHEMBL4849503 | — | Ki | = | 346.94 | nM | 6.46 |
| CHEMBL4849015 | — | Ki | = | 453.33 | nM | 6.34 |
| CHEMBL4875988 | — | Ki | = | 1307.69 | nM | 5.88 |
| CHEMBL4862733 | — | Ki | = | 1545.45 | nM | 5.81 |
| CHEMBL4878251 | — | Ki | = | 1789.47 | nM | 5.75 |
| CHEMBL4873312 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL4869562 | — | Ki | = | 2125.0 | nM | 5.67 |
| CHEMBL4859208 | — | Ki | = | 2428.57 | nM | 5.62 |
| CHEMBL4870760 | — | Ki | = | 2615.38 | nM | 5.58 |
| CHEMBL4852827 | — | Ki | = | 2833.33 | nM | 5.55 |
| CHEMBL4853571 | — | Ki | = | 2833.33 | nM | 5.55 |
| CHEMBL4851237 | — | Ki | = | 2833.33 | nM | 5.55 |
| CHEMBL4870293 | — | Ki | = | 2833.33 | nM | 5.55 |
| CHEMBL4861959 | — | Ki | = | 3090.91 | nM | 5.51 |
| CHEMBL4869951 | — | Ki | = | 3090.3 | nM | 5.51 |
| CHEMBL4874242 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL4871032 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL4874175 | — | Ki | = | 4857.14 | nM | 5.31 |
| CHEMBL4862515 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL4855745 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL4868001 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL4855392 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL4855191 | — | Ki | > | 5000.0 | nM | - |