Assay Detail
Functional
CHEMBL4822855
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Inhibition of clonogenicity in human DLD-1 cells assessed as reduction in number of colony formation incubated for 72 hrs followed by culturing in fresh compound-free medium for 7 days by crystal violet staining based analysis
8
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.81 | 4.96 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4281802 | — | — | 2 | 4.96 |
| CHEMBL1389174 | — | — | 2 | 4.80 |
| CHEMBL4293874 | — | — | 2 | 4.68 |
| CHEMBL4855678 | — | — | 1 | - |
| CHEMBL4876581 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4281802 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1389174 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4293874 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4855678 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4876581 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1389174 | — | Inhibition | - | % | - | |
| CHEMBL4293874 | — | Inhibition | - | % | - | |
| CHEMBL4281802 | — | Inhibition | - | % | - |