Assay Detail
Binding
CHEMBL4822910
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Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured by Ellman's method
21
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of garlic-related unsymmetrical thiosulfonates as potential Alzheimer's disease therapeutics: In vitro and in silico study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.86 | 7.84 |
| Ki | 10 | 6.90 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 7.84 |
| CHEMBL4860610 | — | — | 2 | 7.76 |
| CHEMBL4871975 | — | — | 2 | 7.42 |
| CHEMBL4868918 | — | — | 2 | 6.99 |
| CHEMBL4852721 | — | — | 2 | 6.99 |
| CHEMBL4863431 | — | — | 2 | 6.70 |
| CHEMBL4858117 | — | — | 2 | 6.70 |
| CHEMBL4875944 | — | — | 2 | 6.70 |
| CHEMBL4845755 | — | — | 2 | 6.68 |
| CHEMBL4867081 | — | — | 2 | 6.67 |
| CHEMBL1995010 | — | — | 2 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL4860610 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL4871975 | — | Ki | = | 37.9 | nM | 7.42 |
| CHEMBL4860610 | — | IC50 | = | 53.3 | nM | 7.27 |
| CHEMBL4871975 | — | IC50 | = | 84.5 | nM | 7.07 |
| CHEMBL4852721 | — | Ki | = | 102.1 | nM | 6.99 |
| CHEMBL4868918 | — | Ki | = | 102.6 | nM | 6.99 |
| CHEMBL4868918 | — | IC50 | = | 117.9 | nM | 6.93 |
| CHEMBL4852721 | — | IC50 | = | 159.4 | nM | 6.80 |
| CHEMBL4863431 | — | Ki | = | 198.7 | nM | 6.70 |
| CHEMBL4858117 | — | Ki | = | 201.2 | nM | 6.70 |
| CHEMBL4875944 | — | IC50 | = | 201.5 | nM | 6.70 |
| CHEMBL4858117 | — | IC50 | = | 202.5 | nM | 6.69 |
| CHEMBL4845755 | — | Ki | = | 207.6 | nM | 6.68 |
| CHEMBL4867081 | — | IC50 | = | 214.3 | nM | 6.67 |
| CHEMBL1995010 | — | Ki | = | 217.6 | nM | 6.66 |
| CHEMBL4875944 | — | Ki | = | 251.5 | nM | 6.60 |
| CHEMBL4867081 | — | Ki | = | 302.5 | nM | 6.52 |
| CHEMBL4845755 | — | IC50 | = | 302.7 | nM | 6.52 |
| CHEMBL4863431 | — | IC50 | = | 314.5 | nM | 6.50 |
| CHEMBL1995010 | — | IC50 | = | 318.5 | nM | 6.50 |