Assay Detail
Binding
CHEMBL4822912
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Inhibition of recombinant human AChE using acetylthiocholine as substrate by DTNB-reagent based Ellman's method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.25 | 8.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL536047 | — | — | 1 | 8.79 |
| CHEMBL4556281 | — | — | 1 | 8.20 |
| CHEMBL4856400 | — | — | 1 | 7.93 |
| CHEMBL4878434 | — | — | 1 | 7.92 |
| CHEMBL292314 | — | — | 1 | 7.70 |
| CHEMBL4874244 | — | — | 1 | 7.64 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.50 |
| CHEMBL4850590 | — | — | 1 | 5.58 |
| CHEMBL1256415 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL536047 | — | IC50 | = | 1.64 | nM | 8.79 |
| CHEMBL4556281 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4856400 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL4878434 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL292314 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4874244 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL95 | TACRINE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4850590 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL1256415 | — | IC50 | = | 10000.0 | nM | 5.00 |