Assay Detail
Binding
CHEMBL4822913
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human BuChE using butyrylthiocholine as substrate by Ellman's method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Huprine Y - Tryptophan heterodimers with potential implication to Alzheimer's disease treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.57 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4556281 | — | — | 1 | 8.04 |
| CHEMBL4856400 | — | — | 1 | 7.34 |
| CHEMBL4874244 | — | — | 1 | 7.17 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.10 |
| CHEMBL4878434 | — | — | 1 | 7.07 |
| CHEMBL536047 | — | — | 1 | 6.45 |
| CHEMBL292314 | — | — | 1 | 5.75 |
| CHEMBL4850590 | — | — | 1 | 5.42 |
| CHEMBL1256415 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4556281 | — | IC50 | = | 9.07 | nM | 8.04 |
| CHEMBL4856400 | — | IC50 | = | 45.7 | nM | 7.34 |
| CHEMBL4874244 | — | IC50 | = | 68.3 | nM | 7.17 |
| CHEMBL95 | TACRINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4878434 | — | IC50 | = | 84.5 | nM | 7.07 |
| CHEMBL536047 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL292314 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4850590 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL1256415 | — | IC50 | = | 17600.0 | nM | 4.75 |