Assay Detail
Functional
CHEMBL4823147
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Increase of PGRN level in mouse microglial BV-2 cell relative to control
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of quinuclidine modulators of cellular progranulin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 6.00 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4867615 | — | — | 1 | 6.84 |
| CHEMBL4873492 | — | — | 1 | 6.65 |
| CHEMBL4875543 | — | — | 1 | 6.61 |
| CHEMBL4850216 | — | — | 1 | 6.59 |
| CHEMBL4855033 | — | — | 1 | 6.58 |
| CHEMBL4857445 | — | — | 1 | 6.47 |
| CHEMBL4858420 | — | — | 1 | 6.24 |
| CHEMBL4857341 | — | — | 1 | 6.09 |
| CHEMBL4877465 | — | — | 1 | 6.05 |
| CHEMBL4860623 | — | — | 1 | 5.99 |
| CHEMBL4854502 | — | — | 1 | 5.96 |
| CHEMBL4852396 | — | — | 1 | 5.90 |
| CHEMBL1734 | SOLIFENACIN | 4.0 | 1 | 5.89 |
| CHEMBL4855820 | — | — | 1 | 5.79 |
| CHEMBL4847917 | — | — | 1 | 5.77 |
| CHEMBL606902 | — | — | 1 | 5.74 |
| CHEMBL4846158 | — | — | 1 | 5.70 |
| CHEMBL4859485 | — | — | 1 | 5.69 |
| CHEMBL4847855 | — | — | 1 | 5.58 |
| CHEMBL4870196 | — | — | 1 | 5.54 |
| CHEMBL4852022 | — | — | 1 | 5.51 |
| CHEMBL4862923 | — | — | 1 | 5.46 |
| CHEMBL4850699 | — | — | 1 | 5.45 |
| CHEMBL4857683 | — | — | 1 | - |
| CHEMBL4850105 | — | — | 1 | - |
| CHEMBL4855235 | — | — | 1 | - |
| CHEMBL4863434 | — | — | 1 | - |
| CHEMBL4869165 | — | — | 1 | - |
| CHEMBL4871313 | — | — | 1 | - |
| CHEMBL4850131 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4867615 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4873492 | — | EC50 | = | 222.0 | nM | 6.65 |
| CHEMBL4875543 | — | EC50 | = | 247.0 | nM | 6.61 |
| CHEMBL4850216 | — | EC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4855033 | — | EC50 | = | 265.0 | nM | 6.58 |
| CHEMBL4857445 | — | EC50 | = | 339.0 | nM | 6.47 |
| CHEMBL4858420 | — | EC50 | = | 574.0 | nM | 6.24 |
| CHEMBL4857341 | — | EC50 | = | 811.0 | nM | 6.09 |
| CHEMBL4877465 | — | EC50 | = | 895.0 | nM | 6.05 |
| CHEMBL4860623 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4854502 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4852396 | — | EC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL1734 | SOLIFENACIN | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4855820 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4847917 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL606902 | — | EC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4846158 | — | EC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4859485 | — | EC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL4847855 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4870196 | — | EC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL4852022 | — | EC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4862923 | — | EC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL4850699 | — | EC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL4857683 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4850105 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4855235 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4863434 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4869165 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4871313 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4850131 | — | EC50 | > | 10000.0 | nM | - |