Compound Detail
CHEMBL4852022
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Basic Information
| ChEMBL ID | CHEMBL4852022 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UIMJNRWELLWSGW-MTQWGCILSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
446.5
MW (Da)
5.83
ALogP
2
HBA
0
HBD
6.5
PSA (Ų)
0.53
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 5.51 | 5.51 | 3070.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 3070.0 | nM | 5.51 | Increase of PGRN level in mouse microglial BV-2 cell relative to control | 34153473 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34153473 | 10.1016/j.bmcl.2021.128209 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine