Assay Detail
Binding
CHEMBL4823577
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Inhibition of AXL (unknown origin) using poly [Glu, Tyr] 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.90 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871310 | — | — | 1 | 9.10 |
| CHEMBL4873571 | — | — | 1 | 9.05 |
| CHEMBL4861161 | — | — | 1 | 8.77 |
| CHEMBL4858048 | — | — | 1 | 8.72 |
| CHEMBL4863290 | — | — | 1 | 8.56 |
| CHEMBL4869458 | — | — | 1 | 8.51 |
| CHEMBL4864676 | — | — | 1 | 8.43 |
| CHEMBL3301622 | GILTERITINIB | 4.0 | 1 | 8.34 |
| CHEMBL3809489 | BEMCENTINIB | 2.0 | 1 | 8.32 |
| CHEMBL4846125 | — | — | 1 | 8.31 |
| CHEMBL4867669 | — | — | 1 | 8.26 |
| CHEMBL4855681 | — | — | 1 | 8.24 |
| CHEMBL4856526 | — | — | 1 | 8.17 |
| CHEMBL4856234 | — | — | 1 | 8.10 |
| CHEMBL4875798 | — | — | 1 | 8.07 |
| CHEMBL4851321 | — | — | 1 | 8.06 |
| CHEMBL4875876 | — | — | 1 | 8.06 |
| CHEMBL4846678 | — | — | 1 | 7.98 |
| CHEMBL4856142 | — | — | 1 | 7.89 |
| CHEMBL4853182 | — | — | 1 | 7.78 |
| CHEMBL4848473 | — | — | 1 | 7.76 |
| CHEMBL4861226 | — | — | 1 | 7.69 |
| CHEMBL4864426 | — | — | 1 | 7.66 |
| CHEMBL4863687 | — | — | 1 | 7.59 |
| CHEMBL4872759 | — | — | 1 | 7.58 |
| CHEMBL4849593 | — | — | 1 | 7.34 |
| CHEMBL4858649 | — | — | 1 | 7.23 |
| CHEMBL4866212 | — | — | 1 | 6.82 |
| CHEMBL4856528 | — | — | 1 | 6.75 |
| CHEMBL4856829 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871310 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4873571 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4861161 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4858048 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4863290 | — | IC50 | = | 2.75 | nM | 8.56 |
| CHEMBL4869458 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4864676 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3301622 | GILTERITINIB | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3809489 | BEMCENTINIB | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4846125 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4867669 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4855681 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4856526 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4856234 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4875798 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4851321 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4875876 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4846678 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL4856142 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4853182 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL4848473 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL4861226 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL4864426 | — | IC50 | = | 21.9 | nM | 7.66 |
| CHEMBL4863687 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL4872759 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4849593 | — | IC50 | = | 45.6 | nM | 7.34 |
| CHEMBL4858649 | — | IC50 | = | 58.3 | nM | 7.23 |
| CHEMBL4866212 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4856528 | — | IC50 | = | 178.6 | nM | 6.75 |
| CHEMBL4856829 | — | IC50 | = | 184.8 | nM | 6.73 |
| CHEMBL4845715 | — | IC50 | = | 253.9 | nM | 6.59 |
| CHEMBL4879206 | — | IC50 | = | 395.7 | nM | 6.40 |
| CHEMBL4863885 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4848206 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4864950 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4862247 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4848709 | — | IC50 | > | 1000.0 | nM | - |