Assay Detail
Binding
CHEMBL4823699
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Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as substrate incubated for 30 mins in presence of ATP by ELISA
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 8.50 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4850755 | — | — | 1 | 10.00 |
| CHEMBL4858310 | — | — | 1 | 9.70 |
| CHEMBL4862803 | — | — | 1 | 9.52 |
| CHEMBL4852400 | — | — | 1 | 9.40 |
| CHEMBL4792737 | — | — | 1 | 9.30 |
| CHEMBL4857803 | — | — | 1 | 9.22 |
| CHEMBL4853948 | — | — | 1 | 9.05 |
| CHEMBL4852763 | — | — | 1 | 9.00 |
| CHEMBL4845919 | — | — | 1 | 9.00 |
| CHEMBL4878312 | — | — | 1 | 9.00 |
| CHEMBL4872830 | — | — | 1 | 9.00 |
| CHEMBL4867495 | — | — | 1 | 8.70 |
| CHEMBL4874640 | — | — | 1 | 8.70 |
| CHEMBL4866506 | — | — | 1 | 8.52 |
| CHEMBL4856420 | — | — | 1 | 8.40 |
| CHEMBL4879094 | — | — | 1 | 8.40 |
| CHEMBL4858974 | — | — | 1 | 8.22 |
| CHEMBL4873212 | — | — | 1 | 8.22 |
| CHEMBL4846084 | — | — | 1 | 8.10 |
| CHEMBL4869283 | — | — | 1 | 7.96 |
| CHEMBL4849786 | — | — | 1 | 7.64 |
| CHEMBL4874992 | — | — | 1 | 7.60 |
| CHEMBL4873551 | — | — | 1 | 7.52 |
| CHEMBL4852165 | — | — | 1 | 7.06 |
| CHEMBL4872482 | — | — | 1 | 6.96 |
| CHEMBL4868624 | — | — | 1 | 6.80 |
| CHEMBL4851518 | — | — | 1 | - |
| CHEMBL4851148 | — | — | 1 | - |
| CHEMBL4850102 | — | — | 1 | - |
| CHEMBL4853674 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4850755 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL4858310 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL4862803 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL4852400 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL4792737 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4857803 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4853948 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4852763 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4845919 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4878312 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4872830 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4867495 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4874640 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4866506 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4879094 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4856420 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4858974 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4873212 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4846084 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4869283 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4849786 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL4874992 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4873551 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4852165 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL4872482 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4868624 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL4851518 | — | Ki | > | 900.0 | nM | - |
| CHEMBL4851148 | — | Ki | > | 1600.0 | nM | - |
| CHEMBL4850102 | — | Ki | > | 1600.0 | nM | - |
| CHEMBL4853674 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4854138 | — | Ki | > | 1200.0 | nM | - |
| CHEMBL4872413 | — | Ki | > | 1200.0 | nM | - |