Assay Detail
Binding
CHEMBL4823701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 mins in presence of ATP at Km concentration by luminescence assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 3-kinase catalytic subunit type 3 (CHEMBL1075165) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.02 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4862803 | — | — | 1 | 8.40 |
| CHEMBL4857803 | — | — | 1 | 8.30 |
| CHEMBL4852400 | — | — | 1 | 8.22 |
| CHEMBL4850755 | — | — | 1 | 8.10 |
| CHEMBL4873212 | — | — | 1 | 8.05 |
| CHEMBL4792737 | — | — | 1 | 7.82 |
| CHEMBL4878312 | — | — | 1 | 7.80 |
| CHEMBL4858310 | — | — | 1 | 7.68 |
| CHEMBL4874992 | — | — | 1 | 7.46 |
| CHEMBL4858974 | — | — | 1 | 7.41 |
| CHEMBL4873551 | — | — | 1 | 7.31 |
| CHEMBL4872830 | — | — | 1 | 7.30 |
| CHEMBL4874640 | — | — | 1 | 7.01 |
| CHEMBL4866506 | — | — | 1 | 6.96 |
| CHEMBL4879094 | — | — | 1 | 6.89 |
| CHEMBL4846084 | — | — | 1 | 6.77 |
| CHEMBL4852165 | — | — | 1 | 6.57 |
| CHEMBL4851518 | — | — | 1 | 6.20 |
| CHEMBL4856420 | — | — | 1 | 6.12 |
| CHEMBL4852763 | — | — | 1 | 6.08 |
| CHEMBL4867495 | — | — | 1 | 6.06 |
| CHEMBL4872413 | — | — | 1 | 6.04 |
| CHEMBL4853948 | — | — | 1 | 5.82 |
| CHEMBL4845919 | — | — | 1 | 5.75 |
| CHEMBL4868624 | — | — | 1 | 5.48 |
| CHEMBL4851148 | — | — | 1 | - |
| CHEMBL4850102 | — | — | 1 | - |
| CHEMBL4869283 | — | — | 1 | - |
| CHEMBL4872482 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4862803 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4857803 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4852400 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4850755 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL4873212 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL4792737 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL4878312 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4858310 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL4874992 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL4858974 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL4873551 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL4872830 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL4874640 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL4866506 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4879094 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL4846084 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4852165 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL4851518 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL4856420 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL4852763 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL4867495 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL4872413 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL4853948 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL4845919 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL4868624 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL4851148 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL4850102 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL4869283 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL4872482 | — | Ki | - | — | - |