Assay Detail
Functional
CHEMBL4823731
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Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by Cell Counting Kit-8 assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective FLT3 Inhibitor (<i>Z</i>)-<i>N</i>-(5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-4-methyl-1<i>H</i>-pyrrol-3-yl)-3-(pyrrolidin-1-yl)propanamide with Improved Drug-like Properties and Superior Efficacy in FLT3-ITD-Positive Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.28 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4867485 | — | — | 1 | 7.68 |
| CHEMBL4869059 | — | — | 1 | 7.63 |
| CHEMBL4852288 | — | — | 1 | 7.54 |
| CHEMBL4868092 | — | — | 1 | 7.54 |
| CHEMBL4864382 | — | — | 1 | 7.52 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.50 |
| CHEMBL4877838 | — | — | 1 | 7.49 |
| CHEMBL4862737 | — | — | 1 | 7.46 |
| CHEMBL4860305 | — | — | 1 | 7.46 |
| CHEMBL4861526 | — | — | 1 | 7.43 |
| CHEMBL4117795 | — | — | 1 | 7.39 |
| CHEMBL4857231 | — | — | 1 | 7.38 |
| CHEMBL4851401 | — | — | 1 | 7.36 |
| CHEMBL4853071 | — | — | 1 | 7.35 |
| CHEMBL4865208 | — | — | 1 | 7.30 |
| CHEMBL4848539 | — | — | 1 | 7.29 |
| CHEMBL4868929 | — | — | 1 | 7.29 |
| CHEMBL4846119 | — | — | 1 | 7.26 |
| CHEMBL4856922 | — | — | 1 | 7.23 |
| CHEMBL4860759 | — | — | 1 | 7.21 |
| CHEMBL4858641 | — | — | 1 | 7.16 |
| CHEMBL4866775 | — | — | 1 | 7.11 |
| CHEMBL4862765 | — | — | 1 | 7.11 |
| CHEMBL4846256 | — | — | 1 | 7.09 |
| CHEMBL4861893 | — | — | 1 | 6.90 |
| CHEMBL4878353 | — | — | 1 | 6.88 |
| CHEMBL4866731 | — | — | 1 | 6.75 |
| CHEMBL4846144 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4867485 | — | IC50 | = | 20.9 | nM | 7.68 |
| CHEMBL4869059 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL4852288 | — | IC50 | = | 28.9 | nM | 7.54 |
| CHEMBL4868092 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL4864382 | — | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL535 | SUNITINIB | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL4877838 | — | IC50 | = | 32.4 | nM | 7.49 |
| CHEMBL4862737 | — | IC50 | = | 34.5 | nM | 7.46 |
| CHEMBL4860305 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL4861526 | — | IC50 | = | 37.2 | nM | 7.43 |
| CHEMBL4117795 | — | IC50 | = | 40.9 | nM | 7.39 |
| CHEMBL4857231 | — | IC50 | = | 41.3 | nM | 7.38 |
| CHEMBL4851401 | — | IC50 | = | 44.2 | nM | 7.36 |
| CHEMBL4853071 | — | IC50 | = | 44.8 | nM | 7.35 |
| CHEMBL4865208 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4848539 | — | IC50 | = | 50.7 | nM | 7.29 |
| CHEMBL4868929 | — | IC50 | = | 51.8 | nM | 7.29 |
| CHEMBL4846119 | — | IC50 | = | 54.4 | nM | 7.26 |
| CHEMBL4856922 | — | IC50 | = | 58.6 | nM | 7.23 |
| CHEMBL4860759 | — | IC50 | = | 61.5 | nM | 7.21 |
| CHEMBL4858641 | — | IC50 | = | 69.9 | nM | 7.16 |
| CHEMBL4866775 | — | IC50 | = | 78.6 | nM | 7.11 |
| CHEMBL4862765 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4846256 | — | IC50 | = | 81.7 | nM | 7.09 |
| CHEMBL4861893 | — | IC50 | = | 124.8 | nM | 6.90 |
| CHEMBL4878353 | — | IC50 | = | 132.8 | nM | 6.88 |
| CHEMBL4866731 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4846144 | — | IC50 | = | 251.5 | nM | 6.60 |