Assay Detail
Binding
CHEMBL4824403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Bacillus anthracis edema factor by cell free assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calmodulin-sensitive adenylate cyclase (CHEMBL5396) ↗| Type | SINGLE PROTEIN |
| Organism | Bacillus anthracis |
Publication
Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.13 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1162433 | ADEFOVIR DIPHOSPHATE | -1.0 | 1 | 7.44 |
| CHEMBL4853492 | — | — | 1 | 6.63 |
| CHEMBL4855382 | — | — | 1 | 6.37 |
| CHEMBL4848421 | — | — | 1 | 6.15 |
| CHEMBL4858677 | — | — | 1 | 5.88 |
| CHEMBL4852011 | — | — | 1 | 5.30 |
| CHEMBL4852594 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1162433 | ADEFOVIR DIPHOSPHATE | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4853492 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL4855382 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL4848421 | — | IC50 | = | 704.0 | nM | 6.15 |
| CHEMBL4858677 | — | IC50 | = | 1335.0 | nM | 5.88 |
| CHEMBL4852011 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL4852594 | — | IC50 | = | 7813.0 | nM | 5.11 |