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Assay Detail

CHEMBL4824671

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human glomerular mesangial cells incubated for 12 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type Glomerular mesangial cell
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
Gou S, Li B, Ouyang X, Ba Z, Zhong C, Zhang T, Chang L, Zhu Y, Zhang J, Zhu N, Zhang Y, Liu H, Ni J.
J Med Chem (2021) 64 : 11247 -11266
PubMed 34180670 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.46 5.83

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL412927 MELITTIN 1 5.83
CHEMBL4860493 1 4.95
CHEMBL4850509 1 4.70
CHEMBL4862426 1 4.60
CHEMBL4853738 1 4.41
CHEMBL4871749 1 4.39
CHEMBL4874973 1 4.32
CHEMBL4859995 1 4.30
CHEMBL4870321 1 4.28
CHEMBL4871296 1 4.10
CHEMBL4865196 1 4.05
CHEMBL4855065 1 4.04
CHEMBL4845719 1 4.01
CHEMBL4865224 1 -
CHEMBL2397513 1 -
CHEMBL4850027 1 -
CHEMBL2396875 ANOPLIN 1 -
CHEMBL4852506 1 -
CHEMBL4845856 1 -
CHEMBL4862255 1 -
CHEMBL4877165 1 -
CHEMBL4877580 1 -
CHEMBL4858900 1 -
CHEMBL4859713 1 -
CHEMBL4854087 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL412927 MELITTIN IC50 = 1490.0 nM 5.83
CHEMBL4860493 IC50 = 11240.0 nM 4.95
CHEMBL4850509 IC50 = 19770.0 nM 4.70
CHEMBL4862426 IC50 = 25170.0 nM 4.60
CHEMBL4853738 IC50 = 38970.0 nM 4.41
CHEMBL4871749 IC50 = 40250.0 nM 4.39
CHEMBL4874973 IC50 = 48210.0 nM 4.32
CHEMBL4859995 IC50 = 49490.0 nM 4.30
CHEMBL4870321 IC50 = 52620.0 nM 4.28
CHEMBL4871296 IC50 = 80210.0 nM 4.10
CHEMBL4865196 IC50 = 88890.0 nM 4.05
CHEMBL4855065 IC50 = 91880.0 nM 4.04
CHEMBL4845719 IC50 = 98280.0 nM 4.01
CHEMBL4865224 IC50 = 104530.0 nM -
CHEMBL2397513 IC50 >= 512000.0 nM -
CHEMBL4850027 IC50 >= 512000.0 nM -
CHEMBL2396875 ANOPLIN IC50 >= 512000.0 nM -
CHEMBL4852506 IC50 >= 512000.0 nM -
CHEMBL4845856 IC50 = 209210.0 nM -
CHEMBL4862255 IC50 >= 512000.0 nM -
CHEMBL4877165 IC50 >= 512000.0 nM -
CHEMBL4877580 IC50 >= 512000.0 nM -
CHEMBL4858900 IC50 >= 512000.0 nM -
CHEMBL4859713 IC50 >= 512000.0 nM -
CHEMBL4854087 IC50 >= 512000.0 nM -