Assay Detail
Functional
CHEMBL4824781
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of GLP1R (unknown origin) CRE-bla expressed in CHO-K1 cells assessed as receptor potency incubated for 1 hrs by time resolved fluorescence resonance energy transfer immunoassay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of double fatty chain-modified glucagon-like peptide-1 conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 10.31 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4867885 | — | — | 1 | 11.00 |
| CHEMBL4875374 | — | — | 1 | 10.85 |
| CHEMBL2108724 | SEMAGLUTIDE | 4.0 | 1 | 10.73 |
| CHEMBL4866366 | — | — | 1 | 10.56 |
| CHEMBL4850914 | — | — | 1 | 10.14 |
| CHEMBL4850528 | — | — | 1 | 10.10 |
| CHEMBL4852358 | — | — | 1 | 9.88 |
| CHEMBL4858631 | — | — | 1 | 9.85 |
| CHEMBL4870408 | — | — | 1 | 9.70 |
| CHEMBL4872171 | — | — | 1 | - |
| CHEMBL4863917 | — | — | 1 | - |
| CHEMBL4847183 | — | — | 1 | - |
| CHEMBL4870050 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4867885 | — | EC50 | = | 0.0101 | nM | 11.00 |
| CHEMBL4875374 | — | EC50 | = | 0.0142 | nM | 10.85 |
| CHEMBL2108724 | SEMAGLUTIDE | EC50 | = | 0.0187 | nM | 10.73 |
| CHEMBL4866366 | — | EC50 | = | 0.0274 | nM | 10.56 |
| CHEMBL4850914 | — | EC50 | = | 0.0723 | nM | 10.14 |
| CHEMBL4850528 | — | EC50 | = | 0.0788 | nM | 10.10 |
| CHEMBL4852358 | — | EC50 | = | 0.1324 | nM | 9.88 |
| CHEMBL4858631 | — | EC50 | = | 0.1427 | nM | 9.85 |
| CHEMBL4870408 | — | EC50 | = | 0.1997 | nM | 9.70 |
| CHEMBL4872171 | — | EC50 | = | 0.0096 | nM | - |
| CHEMBL4863917 | — | EC50 | = | 0.0066 | nM | - |
| CHEMBL4847183 | — | EC50 | = | 0.0051 | nM | - |
| CHEMBL4870050 | — | EC50 | = | 0.0016 | nM | - |