Assay Detail
Binding
CHEMBL4824939
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PU-H71-FITC3 binding to recombinant full length TRAP1 (unknown origin) incubated for 2 hrs by fluorescence polarization assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Heat shock protein 75 kDa, mitochondrial (CHEMBL1075132) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.60 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866705 | — | — | 1 | 7.24 |
| CHEMBL4863672 | — | — | 1 | 7.21 |
| CHEMBL4864922 | — | — | 1 | 7.20 |
| CHEMBL4869481 | — | — | 1 | 7.18 |
| CHEMBL4879021 | — | — | 1 | 7.12 |
| CHEMBL4866958 | — | — | 1 | 7.09 |
| CHEMBL4876871 | — | — | 1 | 7.08 |
| CHEMBL4863988 | — | — | 1 | 7.05 |
| CHEMBL4871630 | — | — | 1 | 7.00 |
| CHEMBL4068596 | — | — | 1 | 6.84 |
| CHEMBL4857569 | — | — | 1 | 6.77 |
| CHEMBL4860652 | — | — | 1 | 6.75 |
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 6.72 |
| CHEMBL4850126 | — | — | 1 | 6.64 |
| CHEMBL4846028 | — | — | 1 | 6.61 |
| CHEMBL4870087 | — | — | 1 | 6.53 |
| CHEMBL4864235 | — | — | 1 | 6.48 |
| CHEMBL4854861 | — | — | 1 | 6.48 |
| CHEMBL4867384 | — | — | 1 | 6.47 |
| CHEMBL4865186 | — | — | 1 | 6.41 |
| CHEMBL4872173 | — | — | 1 | 6.38 |
| CHEMBL4859919 | — | — | 1 | 6.32 |
| CHEMBL4853048 | — | — | 1 | 6.23 |
| CHEMBL4853988 | — | — | 1 | 6.21 |
| CHEMBL4870476 | — | — | 1 | 6.14 |
| CHEMBL4870579 | — | — | 1 | 6.13 |
| CHEMBL4874124 | — | — | 1 | 5.98 |
| CHEMBL4846176 | — | — | 1 | 5.95 |
| CHEMBL4876733 | — | — | 1 | 5.91 |
| CHEMBL4870963 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866705 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4863672 | — | IC50 | = | 62.4 | nM | 7.21 |
| CHEMBL4864922 | — | IC50 | = | 63.5 | nM | 7.20 |
| CHEMBL4869481 | — | IC50 | = | 65.8 | nM | 7.18 |
| CHEMBL4879021 | — | IC50 | = | 76.6 | nM | 7.12 |
| CHEMBL4866958 | — | IC50 | = | 81.5 | nM | 7.09 |
| CHEMBL4876871 | — | IC50 | = | 82.7 | nM | 7.08 |
| CHEMBL4863988 | — | IC50 | = | 89.9 | nM | 7.05 |
| CHEMBL4871630 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4068596 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4857569 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4860652 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL200102 | PU-H71 | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL4850126 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4846028 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL4870087 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL4864235 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL4854861 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL4867384 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL4865186 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL4872173 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL4859919 | — | IC50 | = | 477.0 | nM | 6.32 |
| CHEMBL4853048 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4853988 | — | IC50 | = | 617.0 | nM | 6.21 |
| CHEMBL4870476 | — | IC50 | = | 728.0 | nM | 6.14 |
| CHEMBL4870579 | — | IC50 | = | 738.0 | nM | 6.13 |
| CHEMBL4874124 | — | IC50 | = | 1037.0 | nM | 5.98 |
| CHEMBL4846176 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4876733 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4870963 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4866835 | — | IC50 | > | 5000.0 | nM | - |