Assay Detail
Binding
CHEMBL4825201
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Inhibition of human ALDH3A1 assessed as NADH formation using propionaldehyde as substrate by spectrophotometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldehyde dehydrogenase, dimeric NADP-preferring (CHEMBL3578) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.63 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871374 | — | — | 1 | 5.84 |
| CHEMBL4855040 | — | — | 1 | 5.72 |
| CHEMBL4845791 | — | — | 1 | 5.67 |
| CHEMBL4854627 | — | — | 1 | 5.64 |
| CHEMBL4862473 | — | — | 1 | 5.58 |
| CHEMBL4871242 | — | — | 1 | 5.50 |
| CHEMBL4847630 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871374 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL4855040 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4845791 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4854627 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4862473 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL4871242 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL4847630 | — | IC50 | = | 3270.0 | nM | 5.49 |