Assay Detail
Binding
CHEMBL4825321
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Akt (unknown origin)
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase AKT (CHEMBL2111353) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.34 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3919089 | — | — | 1 | 9.00 |
| CHEMBL4853207 | — | — | 1 | 8.85 |
| CHEMBL3962807 | — | — | 1 | 8.66 |
| CHEMBL3922798 | — | — | 1 | 8.40 |
| CHEMBL3931504 | — | — | 1 | 8.38 |
| CHEMBL3900512 | — | — | 1 | 8.32 |
| CHEMBL3917410 | — | — | 1 | 8.18 |
| CHEMBL3916864 | — | — | 1 | 8.16 |
| CHEMBL4876889 | — | — | 1 | 8.14 |
| CHEMBL3931848 | — | — | 1 | 8.04 |
| CHEMBL3911401 | — | — | 1 | 7.92 |
| CHEMBL3949501 | — | — | 1 | 7.80 |
| CHEMBL3903522 | — | — | 1 | 7.64 |
| CHEMBL3936329 | — | — | 1 | 7.08 |
| CHEMBL3916957 | — | — | 1 | 6.85 |
| CHEMBL3933645 | — | — | 1 | 6.64 |
| CHEMBL3941307 | — | — | 1 | 6.58 |
| CHEMBL3982464 | — | — | 1 | 6.46 |
| CHEMBL3932445 | — | — | 1 | 6.46 |
| CHEMBL3964789 | — | — | 1 | 6.29 |
| CHEMBL3922417 | — | — | 1 | 6.07 |
| CHEMBL3929608 | — | — | 1 | 6.06 |
| CHEMBL3978717 | — | — | 1 | 6.03 |
| CHEMBL3964726 | — | — | 1 | 5.80 |
| CHEMBL3925871 | — | — | 1 | 5.66 |
| CHEMBL3935451 | — | — | 1 | - |
| CHEMBL3912964 | — | — | 1 | - |
| CHEMBL3919663 | — | — | 1 | - |
| CHEMBL3948645 | — | — | 1 | - |
| CHEMBL3928625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3919089 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4853207 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3962807 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3922798 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3931504 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3900512 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3917410 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3916864 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4876889 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL3931848 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL3911401 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3949501 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3903522 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3936329 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3916957 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3933645 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3941307 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3982464 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3932445 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3964789 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL3922417 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3929608 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3978717 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL3964726 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3925871 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3935451 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3912964 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3919663 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3948645 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3928625 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3935218 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3890900 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3920854 | — | IC50 | > | 1000.0 | nM | - |