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Assay Detail

CHEMBL4825486

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania amazonensis MHOM/BR/77/LTB 0016 promastigotes assessed as inhibition of parasite growth incubated for 72 hrs by resazurin dye based assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania amazonensis
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania amazonensis (CHEMBL612877)
Type ORGANISM
Organism Leishmania amazonensis

Publication

Monocyclic Nitro-heteroaryl Nitrones with Dual Mechanism of Activation: Synthesis and Antileishmanial Activity.
Pacheco JDS, Costa DS, Cunha-Júnior EF, Andrade-Neto VV, Fairlamb AH, Wyllie S, Goulart MOF, Santos DC, Silva TL, Alves MA, Costa PRR, Dias AG, Torres-Santos EC.
ACS Med Chem Lett (2021) 12 : 1405 -1412
PubMed 34531949 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.36 6.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4876294 1 6.68
CHEMBL4847822 1 5.82
CHEMBL4852509 1 5.70
CHEMBL4870182 1 5.29
CHEMBL125 MILTEFOSINE 4.0 1 5.15
CHEMBL4860087 1 5.03
CHEMBL4871887 1 5.01
CHEMBL4878658 1 4.95
CHEMBL351937 1 4.60
CHEMBL164236 1 -
CHEMBL328441 2-THIOPHENENECARBOXALDEHYDE 1 -
CHEMBL189362 FURFURAL 1 -
CHEMBL4872421 1 -
CHEMBL4861994 1 -
CHEMBL554606 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4876294 IC50 = 210.0 nM 6.68
CHEMBL4847822 IC50 = 1500.0 nM 5.82
CHEMBL4852509 IC50 = 1990.0 nM 5.70
CHEMBL4870182 IC50 = 5110.0 nM 5.29
CHEMBL125 MILTEFOSINE IC50 = 7010.0 nM 5.15
CHEMBL4860087 IC50 = 9370.0 nM 5.03
CHEMBL4871887 IC50 = 9720.0 nM 5.01
CHEMBL4878658 IC50 = 11320.0 nM 4.95
CHEMBL351937 IC50 = 25200.0 nM 4.60
CHEMBL164236 IC50 > 100000.0 nM -
CHEMBL328441 2-THIOPHENENECARBOXALDEHYDE IC50 > 100000.0 nM -
CHEMBL189362 FURFURAL IC50 > 100000.0 nM -
CHEMBL4872421 IC50 > 100000.0 nM -
CHEMBL4861994 IC50 > 100000.0 nM -
CHEMBL554606 IC50 > 100000.0 nM -