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Compound Detail

CHEMBL164236

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O=Cc1ccc([N+](=O)[O-])cc1

Basic Information

ChEMBL ID CHEMBL164236
Phase Preclinical
Structure Type MOL
InChI Key BXRFQSNOROATLV-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
14
Publications
0
Known Names

Molecular Properties

151.1
MW (Da)
1.41
ALogP
3
HBA
0
HBD
60.2
PSA (Ų)
0.36
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C7H5NO3
MW 151.12
Aromatic Rings 1
Heavy Atoms 11
NP-Likeness -0.83

Activity Summary

IC50 1 meas. best 4.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
B16-F10
CHEMBL612656
IC50 4.15 4.15 70740.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
B16-F10 IC50 = 70740.0 nM 4.15 Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability 30594028

Literature References

PubMed DOI Target Context # Activities
34531949 10.1021/acsmedchemlett.1c00193 Leishmania amazonensis 2
35212533 10.1021/acs.jmedchem.1c01367 Aldehyde dehydrogenase, dimeric NADP-preferring 2
1995902 10.1021/jm00106a046 Salmonella typhimurium 1
1995902 10.1021/jm00106a046 No relevant target 1
17512740 10.1016/j.bmc.2007.05.013 Mus musculus 1
28197313 10.1021/acsmedchemlett.6b00417 Myeloperoxidase 1
30826292 10.1016/j.bmcl.2019.02.025 Unchecked 1
31097402 10.1016/j.bmc.2019.05.001 Sodium- and chloride-dependent GABA transporter 1 1
30376325 10.1021/acs.jmedchem.8b01602 Sodium- and chloride-dependent GABA transporter 1 1
30777661 10.1016/j.bmc.2019.02.015 Sodium- and chloride-dependent GABA transporter 1 1
30594028 10.1016/j.ejmech.2018.11.026 B16-F10 1
34531949 10.1021/acsmedchemlett.1c00193 Peritoneal macrophage 1
34531949 10.1021/acsmedchemlett.1c00193 Leishmania infantum 1
34531949 10.1021/acsmedchemlett.1c00193 No relevant target 1

Data from ChEMBL 36 via Core Engine