Assay Detail
Binding
CHEMBL4825836
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Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.47 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.25 |
| CHEMBL4856565 | — | — | 1 | 7.19 |
| CHEMBL4870207 | — | — | 1 | 7.05 |
| CHEMBL4851050 | — | — | 1 | 7.05 |
| CHEMBL4855598 | — | — | 1 | 7.02 |
| CHEMBL4869520 | — | — | 1 | 7.02 |
| CHEMBL4849362 | — | — | 1 | 6.80 |
| CHEMBL4876551 | — | — | 1 | 6.79 |
| CHEMBL4864527 | — | — | 1 | 6.69 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL4857705 | — | — | 1 | 6.51 |
| CHEMBL4867955 | — | — | 1 | 6.50 |
| CHEMBL4855176 | — | — | 1 | 6.43 |
| CHEMBL4851043 | — | — | 1 | 6.39 |
| CHEMBL4850250 | — | — | 1 | 6.34 |
| CHEMBL4865065 | — | — | 1 | 6.33 |
| CHEMBL4860586 | — | — | 1 | 6.21 |
| CHEMBL4875448 | — | — | 1 | 6.20 |
| CHEMBL4878810 | — | — | 1 | 6.17 |
| CHEMBL4877756 | — | — | 1 | 6.17 |
| CHEMBL4856821 | — | — | 1 | 6.10 |
| CHEMBL4862704 | — | — | 1 | 6.07 |
| CHEMBL4860722 | — | — | 1 | 6.06 |
| CHEMBL4848020 | — | — | 1 | 6.02 |
| CHEMBL4876361 | — | — | 1 | 5.77 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220492 | TOPIRAMATE | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL4856565 | — | Ki | = | 63.9 | nM | 7.19 |
| CHEMBL4870207 | — | Ki | = | 89.5 | nM | 7.05 |
| CHEMBL4851050 | — | Ki | = | 88.1 | nM | 7.05 |
| CHEMBL4855598 | — | Ki | = | 95.1 | nM | 7.02 |
| CHEMBL4869520 | — | Ki | = | 95.4 | nM | 7.02 |
| CHEMBL4849362 | — | Ki | = | 158.4 | nM | 6.80 |
| CHEMBL4876551 | — | Ki | = | 162.1 | nM | 6.79 |
| CHEMBL4864527 | — | Ki | = | 204.5 | nM | 6.69 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4857705 | — | Ki | = | 310.5 | nM | 6.51 |
| CHEMBL4867955 | — | Ki | = | 315.1 | nM | 6.50 |
| CHEMBL4855176 | — | Ki | = | 372.3 | nM | 6.43 |
| CHEMBL4851043 | — | Ki | = | 406.9 | nM | 6.39 |
| CHEMBL4850250 | — | Ki | = | 457.2 | nM | 6.34 |
| CHEMBL4865065 | — | Ki | = | 462.0 | nM | 6.33 |
| CHEMBL4860586 | — | Ki | = | 613.8 | nM | 6.21 |
| CHEMBL4875448 | — | Ki | = | 629.2 | nM | 6.20 |
| CHEMBL4878810 | — | Ki | = | 676.1 | nM | 6.17 |
| CHEMBL4877756 | — | Ki | = | 673.2 | nM | 6.17 |
| CHEMBL4856821 | — | Ki | = | 787.1 | nM | 6.10 |
| CHEMBL4862704 | — | Ki | = | 853.5 | nM | 6.07 |
| CHEMBL4860722 | — | Ki | = | 862.1 | nM | 6.06 |
| CHEMBL4848020 | — | Ki | = | 954.3 | nM | 6.02 |
| CHEMBL4876361 | — | Ki | = | 1700.6 | nM | 5.77 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 5080.0 | nM | 5.29 |