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Assay Detail

CHEMBL4825838

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human CA7 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 7 (CHEMBL2326)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.
Mishra CB, Kumari S, Angeli A, Bua S, Mongre RK, Tiwari M, Supuran CT.
J Med Chem (2021) 64 : 3100 -3114
PubMed 33721499 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 27 7.36 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL750 ZONISAMIDE 4.0 1 9.05
CHEMBL20 ACETAZOLAMIDE 4.0 1 8.60
CHEMBL4857705 1 8.44
CHEMBL4850250 1 7.96
CHEMBL4876361 1 7.94
CHEMBL4862704 1 7.88
CHEMBL4851043 1 7.82
CHEMBL4876551 1 7.80
CHEMBL4875448 1 7.77
CHEMBL4864527 1 7.71
CHEMBL4870207 1 7.69
CHEMBL4855176 1 7.65
CHEMBL4867955 1 7.63
CHEMBL4856821 1 7.63
CHEMBL4856565 1 7.62
CHEMBL4878810 1 7.08
CHEMBL4860722 1 7.06
CHEMBL4855598 1 7.02
CHEMBL220492 TOPIRAMATE 4.0 1 6.93
CHEMBL4848020 1 6.92
CHEMBL4877756 1 6.90
CHEMBL4860586 1 6.79
CHEMBL4851050 1 6.71
CHEMBL4865065 1 6.67
CHEMBL4869520 1 6.66
CHEMBL4849362 1 5.79
CHEMBL1615281 SLC-0111 1.0 1 5.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL750 ZONISAMIDE Ki = 0.9 nM 9.05
CHEMBL20 ACETAZOLAMIDE Ki = 2.5 nM 8.60
CHEMBL4857705 Ki = 3.6 nM 8.44
CHEMBL4850250 Ki = 10.9 nM 7.96
CHEMBL4876361 Ki = 11.5 nM 7.94
CHEMBL4862704 Ki = 13.2 nM 7.88
CHEMBL4851043 Ki = 15.3 nM 7.82
CHEMBL4876551 Ki = 16.0 nM 7.80
CHEMBL4875448 Ki = 16.9 nM 7.77
CHEMBL4864527 Ki = 19.4 nM 7.71
CHEMBL4870207 Ki = 20.6 nM 7.69
CHEMBL4855176 Ki = 22.6 nM 7.65
CHEMBL4867955 Ki = 23.3 nM 7.63
CHEMBL4856821 Ki = 23.6 nM 7.63
CHEMBL4856565 Ki = 23.8 nM 7.62
CHEMBL4878810 Ki = 83.3 nM 7.08
CHEMBL4860722 Ki = 86.6 nM 7.06
CHEMBL4855598 Ki = 94.6 nM 7.02
CHEMBL220492 TOPIRAMATE Ki = 117.0 nM 6.93
CHEMBL4848020 Ki = 120.7 nM 6.92
CHEMBL4877756 Ki = 126.3 nM 6.90
CHEMBL4860586 Ki = 162.2 nM 6.79
CHEMBL4851050 Ki = 194.8 nM 6.71
CHEMBL4865065 Ki = 212.0 nM 6.67
CHEMBL4869520 Ki = 218.0 nM 6.66
CHEMBL4849362 Ki = 1602.0 nM 5.79
CHEMBL1615281 SLC-0111 Ki = 8550.0 nM 5.07