Assay Detail
Binding
CHEMBL4825906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Respiratory syncytial virus A2 fusion protein expressed in HEK293T cells harboring GAL4-NF-kappaB assessed as reduction in cell-cell fusion by luciferase assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human respiratory syncytial virus A2 |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Fusion glycoprotein F0 (CHEMBL3856166) ↗| Type | SINGLE PROTEIN |
| Organism | Human respiratory syncytial virus A (strain A2) |
Publication
Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.13 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4469438 | — | — | 1 | 9.40 |
| CHEMBL4878302 | — | — | 1 | 9.30 |
| CHEMBL4872095 | — | — | 1 | 9.15 |
| CHEMBL4297497 | SISUNATOVIR | 2.0 | 1 | 9.05 |
| CHEMBL4867108 | — | — | 1 | 9.00 |
| CHEMBL4865906 | — | — | 1 | 8.92 |
| CHEMBL4874709 | — | — | 1 | 8.92 |
| CHEMBL4860271 | — | — | 1 | 8.89 |
| CHEMBL4853602 | — | — | 1 | 8.82 |
| CHEMBL4863172 | — | — | 1 | 8.59 |
| CHEMBL4873528 | — | — | 1 | 8.59 |
| CHEMBL4855358 | — | — | 1 | 8.52 |
| CHEMBL4872263 | — | — | 1 | 8.35 |
| CHEMBL4876843 | — | — | 1 | 8.21 |
| CHEMBL4862291 | — | — | 1 | 7.96 |
| CHEMBL4859694 | — | — | 1 | 7.43 |
| CHEMBL4878086 | — | — | 1 | 7.33 |
| CHEMBL4847062 | — | — | 1 | 7.15 |
| CHEMBL4866951 | — | — | 1 | 6.74 |
| CHEMBL4871056 | — | — | 1 | 6.44 |
| CHEMBL4869353 | — | — | 1 | 6.19 |
| CHEMBL4873987 | — | — | 1 | 5.97 |
| CHEMBL4850153 | — | — | 1 | - |
| CHEMBL4878851 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4469438 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4878302 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4872095 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4297497 | SISUNATOVIR | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4867108 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4865906 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4874709 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4860271 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4853602 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4863172 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4873528 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4855358 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4872263 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4876843 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4862291 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL4859694 | — | IC50 | = | 37.2 | nM | 7.43 |
| CHEMBL4878086 | — | IC50 | = | 46.7 | nM | 7.33 |
| CHEMBL4847062 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4866951 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4871056 | — | IC50 | = | 364.5 | nM | 6.44 |
| CHEMBL4869353 | — | IC50 | = | 640.5 | nM | 6.19 |
| CHEMBL4873987 | — | IC50 | = | 1069.5 | nM | 5.97 |
| CHEMBL4850153 | — | IC50 | - | — | - | |
| CHEMBL4878851 | — | IC50 | > | 25000.0 | nM | - |