Assay Detail

CHEMBL4825946

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against Respiratory syncytial virus A by Plaque reduction assay

ChEMBL ↗

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Target

Human orthopneumovirus (CHEMBL613127) ↗

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Human orthopneumovirus (CHEMBL613127) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Human orthopneumovirus

CHEMBL613127

Anchored from Assay target.

Protein identity Human orthopneumovirus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human respiratory syncytial virus
Confidence	1 — Organism
Curated By	Autocuration

Target

Human orthopneumovirus (CHEMBL613127) ↗

Type	ORGANISM
Organism	Human orthopneumovirus

Publication

Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.

Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K.
J Med Chem (2021) 64 : 3658 -3676
PubMed 33729773 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.85	8.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4297497	SISUNATOVIR	2.0	1	8.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4297497	SISUNATOVIR	IC50	=	1.4	nM	8.85