Assay Detail
Functional
CHEMBL4826786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human HCT-116 cells overexpressing MMP9/MAO-A by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Halting colorectal cancer metastasis via novel dual nanomolar MMP-9/MAO-A quinoxaline-based inhibitors; design, synthesis, and evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.47 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871376 | — | — | 1 | 8.25 |
| CHEMBL4852596 | — | — | 1 | 8.23 |
| CHEMBL4862110 | — | — | 1 | 8.13 |
| CHEMBL3408913 | — | — | 1 | 8.12 |
| CHEMBL4878125 | — | — | 1 | 8.05 |
| CHEMBL4859228 | — | — | 1 | 7.97 |
| CHEMBL4859702 | — | — | 1 | 7.89 |
| CHEMBL4859089 | — | — | 1 | 7.83 |
| CHEMBL4846007 | — | — | 1 | 7.83 |
| CHEMBL3409365 | — | — | 1 | 7.80 |
| CHEMBL4867940 | — | — | 1 | 7.78 |
| CHEMBL4866360 | — | — | 1 | 7.74 |
| CHEMBL4863152 | — | — | 1 | 7.73 |
| CHEMBL4869899 | — | — | 1 | 7.73 |
| CHEMBL4860725 | — | — | 1 | 7.70 |
| CHEMBL3408929 | — | — | 1 | 7.65 |
| CHEMBL4859527 | — | — | 1 | 7.44 |
| CHEMBL4850796 | — | — | 1 | 7.34 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.12 |
| CHEMBL4851891 | — | — | 1 | 4.79 |
| CHEMBL4855717 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871376 | — | IC50 | = | 5.567 | nM | 8.25 |
| CHEMBL4852596 | — | IC50 | = | 5.837 | nM | 8.23 |
| CHEMBL4862110 | — | IC50 | = | 7.403 | nM | 8.13 |
| CHEMBL3408913 | — | IC50 | = | 7.636 | nM | 8.12 |
| CHEMBL4878125 | — | IC50 | = | 8.815 | nM | 8.05 |
| CHEMBL4859228 | — | IC50 | = | 10.67 | nM | 7.97 |
| CHEMBL4859702 | — | IC50 | = | 12.85 | nM | 7.89 |
| CHEMBL4859089 | — | IC50 | = | 14.66 | nM | 7.83 |
| CHEMBL4846007 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL3409365 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL4867940 | — | IC50 | = | 16.46 | nM | 7.78 |
| CHEMBL4866360 | — | IC50 | = | 18.27 | nM | 7.74 |
| CHEMBL4863152 | — | IC50 | = | 18.65 | nM | 7.73 |
| CHEMBL4869899 | — | IC50 | = | 18.55 | nM | 7.73 |
| CHEMBL4860725 | — | IC50 | = | 19.84 | nM | 7.70 |
| CHEMBL3408929 | — | IC50 | = | 22.29 | nM | 7.65 |
| CHEMBL4859527 | — | IC50 | = | 36.01 | nM | 7.44 |
| CHEMBL4850796 | — | IC50 | = | 45.94 | nM | 7.34 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 761.45 | nM | 6.12 |
| CHEMBL4851891 | — | IC50 | = | 16316.0 | nM | 4.79 |
| CHEMBL4855717 | — | IC50 | = | 16243.0 | nM | 4.79 |