Assay Detail
Functional
CHEMBL4827627
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Antiproliferative activity against human IGR37 cells assessed as cell growth inhibition after 72 hrs by Cell titer glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGR-37 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Dihydrooxadiazinones as PDE3 Inhibitors for Treating Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.48 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4878539 | — | — | 1 | 9.70 |
| CHEMBL4876937 | — | — | 1 | 9.52 |
| CHEMBL4877229 | — | — | 1 | 9.52 |
| CHEMBL4853029 | — | — | 1 | 9.52 |
| CHEMBL4858628 | — | — | 1 | 9.30 |
| CHEMBL4862024 | — | — | 1 | 9.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4878539 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4876937 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4877229 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4853029 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4858628 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4862024 | — | IC50 | = | 0.5 | nM | 9.30 |