Compound Detail
CHEMBL4858628
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Basic Information
| ChEMBL ID | CHEMBL4858628 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FOMOXZVSLJOJRE-VIFPVBQESA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
330.3
MW (Da)
3.72
ALogP
4
HBA
1
HBD
59.9
PSA (Ų)
0.84
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HeLa CHEMBL399 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| IGR-37 cell line CHEMBL613985 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
| SK-MEL3 CHEMBL614920 | IC50 | 9.22 | 9.22 | 0.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HeLa | IC50 | = | 0.2 | nM | 9.7 | Antiproliferative activity against human HeLa cells assessed as cell growth inhi... | 34267873 |
| IGR-37 cell line | IC50 | = | 0.5 | nM | 9.3 | Antiproliferative activity against human IGR37 cells assessed as cell growth inh... | 34267873 |
| SK-MEL3 | IC50 | = | 0.6 | nM | 9.22 | Antiproliferative activity against human SK-MEL3 cells assessed as cell growth i... | 34267873 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34267873 | 10.1021/acsmedchemlett.1c00317 | HeLa | 1 |
| 34267873 | 10.1021/acsmedchemlett.1c00317 | SK-MEL3 | 1 |
| 34267873 | 10.1021/acsmedchemlett.1c00317 | IGR-37 cell line | 1 |
Data from ChEMBL 36 via Core Engine