Assay Detail
Binding
CHEMBL4827629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full length PDE3B expressed in Sf9 cells measured after 60 mins by [3H]-cAMP Scintillation proximity assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (CHEMBL290) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel Dihydrooxadiazinones as PDE3 Inhibitors for Treating Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.20 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4876937 | — | — | 1 | 8.30 |
| CHEMBL4877229 | — | — | 1 | 8.30 |
| CHEMBL4862024 | — | — | 1 | 8.15 |
| CHEMBL4853029 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4876937 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4877229 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4862024 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4853029 | — | IC50 | = | 9.0 | nM | 8.05 |