Assay Detail
Binding
CHEMBL4827636
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after 30 mins by LC-MS analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Primary hepatocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.66 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4864519 | — | — | 1 | 6.87 |
| CHEMBL4855986 | — | — | 1 | 6.84 |
| CHEMBL4847068 | — | — | 1 | 6.77 |
| CHEMBL4850573 | — | — | 1 | 6.70 |
| CHEMBL4861379 | — | — | 1 | 6.64 |
| CHEMBL4873879 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4864519 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL4855986 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4847068 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4850573 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL4861379 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4873879 | — | IC50 | = | 732.0 | nM | 6.13 |