Assay Detail
Binding
CHEMBL4827647
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ATX assessed as reduction in LPA formation using FS-3 as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by FRET assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.24 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871014 | — | — | 1 | 9.00 |
| CHEMBL4850429 | — | — | 1 | 8.85 |
| CHEMBL4872157 | — | — | 1 | 8.44 |
| CHEMBL4871067 | — | — | 1 | 8.09 |
| CHEMBL4858196 | — | — | 1 | 7.55 |
| CHEMBL4868783 | — | — | 1 | 7.42 |
| CHEMBL4859055 | — | — | 1 | 7.00 |
| CHEMBL1615121 | — | — | 1 | 6.96 |
| CHEMBL4847281 | — | — | 1 | 6.64 |
| CHEMBL4858465 | — | — | 1 | 6.48 |
| CHEMBL4846048 | — | — | 1 | 6.43 |
| CHEMBL4872976 | — | — | 1 | 5.89 |
| CHEMBL4875797 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871014 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4850429 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4872157 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4871067 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4858196 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4868783 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4859055 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1615121 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4847281 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4858465 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4846048 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4872976 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4875797 | — | IC50 | = | 3700.0 | nM | 5.43 |