Assay Detail
Functional
CHEMBL4828085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human PC-3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and antitumor activity evaluation of steroidal oximes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.49 | 4.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859006 | — | — | 1 | 4.86 |
| CHEMBL4856381 | — | — | 1 | 4.84 |
| CHEMBL1629804 | — | — | 1 | 4.67 |
| CHEMBL1629800 | — | — | 1 | 4.64 |
| CHEMBL1629802 | — | — | 1 | 4.33 |
| CHEMBL806 | FLUTAMIDE | 4.0 | 1 | 4.24 |
| CHEMBL2058266 | — | — | 1 | 4.21 |
| CHEMBL4849768 | — | — | 1 | 4.11 |
| CHEMBL4873398 | — | — | 1 | - |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | - |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859006 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL4856381 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL1629804 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL1629800 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL1629802 | — | IC50 | = | 46800.0 | nM | 4.33 |
| CHEMBL806 | FLUTAMIDE | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL2058266 | — | IC50 | = | 62100.0 | nM | 4.21 |
| CHEMBL4849768 | — | IC50 | = | 77900.0 | nM | 4.11 |
| CHEMBL4873398 | — | IC50 | - | — | - | |
| CHEMBL185 | FLUOROURACIL | IC50 | - | — | - | |
| CHEMBL481 | IRINOTECAN | IC50 | - | — | - | |
| CHEMBL44657 | ETOPOSIDE | IC50 | - | — | - |