Assay Detail
Functional
CHEMBL4828086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human WiDr cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and antitumor activity evaluation of steroidal oximes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.56 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859006 | — | — | 1 | 5.04 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.98 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 4.86 |
| CHEMBL4856381 | — | — | 1 | 4.79 |
| CHEMBL1629804 | — | — | 1 | 4.55 |
| CHEMBL4873398 | — | — | 1 | 4.27 |
| CHEMBL2058266 | — | — | 1 | 4.23 |
| CHEMBL1629802 | — | — | 1 | 4.21 |
| CHEMBL4849768 | — | — | 1 | 4.12 |
| CHEMBL1629800 | — | — | 1 | - |
| CHEMBL806 | FLUTAMIDE | 4.0 | 1 | - |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859006 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL4856381 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL1629804 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4873398 | — | IC50 | = | 53400.0 | nM | 4.27 |
| CHEMBL2058266 | — | IC50 | = | 59100.0 | nM | 4.23 |
| CHEMBL1629802 | — | IC50 | = | 60900.0 | nM | 4.21 |
| CHEMBL4849768 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL1629800 | — | IC50 | - | — | - | |
| CHEMBL806 | FLUTAMIDE | IC50 | - | — | - | |
| CHEMBL44657 | ETOPOSIDE | IC50 | - | — | - |