Assay Detail
Binding
CHEMBL4828262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type human full length MKN1 (M1 to L424) expressed in mammalian expression system by HTRF method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 1 (CHEMBL4718) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of 4,6-Disubstituted Pyrido[3,2-<i>d</i>]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4869634 | — | — | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4869634 | — | IC50 | = | 1.0 | nM | 9.00 |