Assay Detail
Binding
CHEMBL4828923
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement [3H]DPCPX from human adenosine A1 receptor expressed in CHO cell membrane incubated for 60 mins by microplate beta scintillation counting based radioligand inhibition assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of adenosine derivatives as A<sub>1</sub>, A<sub>2A</sub>, A<sub>2B</sub> and A<sub>3</sub> adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A<sub>3</sub> agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.93 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113484 | — | — | 1 | 7.10 |
| CHEMBL375190 | — | — | 1 | 6.19 |
| CHEMBL4861092 | — | — | 1 | 6.09 |
| CHEMBL2113406 | — | — | 1 | 6.06 |
| CHEMBL4852007 | — | — | 1 | 5.71 |
| CHEMBL4864883 | — | — | 1 | 5.48 |
| CHEMBL4873585 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113484 | — | Ki | = | 78.8 | nM | 7.10 |
| CHEMBL375190 | — | Ki | = | 646.0 | nM | 6.19 |
| CHEMBL4861092 | — | Ki | = | 803.0 | nM | 6.09 |
| CHEMBL2113406 | — | Ki | = | 864.0 | nM | 6.06 |
| CHEMBL4852007 | — | Ki | = | 1940.0 | nM | 5.71 |
| CHEMBL4864883 | — | Ki | = | 3340.0 | nM | 5.48 |
| CHEMBL4873585 | — | Ki | = | 13300.0 | nM | 4.88 |