Assay Detail
Binding
CHEMBL4829129
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Inhibition of AAK1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.59 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4857123 | — | — | 1 | 9.15 |
| CHEMBL4127773 | — | — | 1 | 8.48 |
| CHEMBL4439128 | — | — | 1 | 8.40 |
| CHEMBL4855590 | — | — | 1 | 8.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4857123 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4127773 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4439128 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4855590 | — | IC50 | = | 4.8 | nM | 8.32 |