Assay Detail
Functional
CHEMBL4829408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 4.57 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078221 | — | — | 1 | 5.72 |
| CHEMBL4862824 | — | — | 1 | 4.82 |
| CHEMBL4867351 | — | — | 1 | 4.79 |
| CHEMBL4847726 | — | — | 1 | 4.76 |
| CHEMBL4856107 | — | — | 1 | 4.73 |
| CHEMBL4860726 | — | — | 1 | 4.67 |
| CHEMBL4867012 | — | — | 1 | 4.66 |
| CHEMBL4870500 | — | — | 1 | 4.64 |
| CHEMBL4858907 | — | — | 1 | 4.64 |
| CHEMBL4877436 | — | — | 1 | 4.62 |
| CHEMBL4852556 | — | — | 1 | 4.61 |
| CHEMBL4858954 | — | — | 1 | 4.61 |
| CHEMBL4859297 | — | — | 1 | 4.60 |
| CHEMBL4863253 | — | — | 1 | 4.58 |
| CHEMBL4873435 | — | — | 1 | 4.57 |
| CHEMBL4854487 | — | — | 1 | 4.56 |
| CHEMBL4853477 | — | — | 1 | 4.53 |
| CHEMBL4870312 | — | — | 1 | 4.53 |
| CHEMBL4877859 | — | — | 1 | 4.52 |
| CHEMBL4868329 | — | — | 1 | 4.51 |
| CHEMBL4855697 | — | — | 1 | 4.51 |
| CHEMBL4857505 | — | — | 1 | 4.49 |
| CHEMBL4862869 | — | — | 1 | 4.48 |
| CHEMBL4868836 | — | — | 1 | 4.48 |
| CHEMBL4857935 | — | — | 1 | 4.47 |
| CHEMBL4847755 | — | — | 1 | 4.46 |
| CHEMBL4846166 | — | — | 1 | 4.46 |
| CHEMBL4864485 | — | — | 1 | 4.46 |
| CHEMBL4851234 | — | — | 1 | 4.46 |
| CHEMBL4858667 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078221 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4862824 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4867351 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL4847726 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4856107 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL4860726 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL4867012 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL4870500 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL4858907 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4877436 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL4858954 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL4852556 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL4859297 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL4863253 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL4873435 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL4854487 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL4853477 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL4870312 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL4877859 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL4855697 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL4868329 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL4857505 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL4862869 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4868836 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL4857935 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL4847755 | — | IC50 | = | 35100.0 | nM | 4.46 |
| CHEMBL4846166 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL4864485 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL4851234 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL4861184 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL4858667 | — | IC50 | = | 35400.0 | nM | 4.45 |
| CHEMBL4853391 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL4874438 | — | IC50 | = | 37500.0 | nM | 4.43 |
| CHEMBL4866819 | — | IC50 | = | 39100.0 | nM | 4.41 |
| CHEMBL4867789 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4854755 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL4856989 | — | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL4867620 | — | IC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL4857843 | — | IC50 | = | 43400.0 | nM | 4.36 |
| CHEMBL4873190 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4850777 | — | IC50 | > | 50000.0 | nM | - |