Assay Detail
ADMET
CHEMBL4829465
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Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | BEAS-2B |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.16 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4850239 | — | — | 1 | 5.43 |
| CHEMBL4297865 | ABIVERTINIB | 3.0 | 1 | 5.43 |
| CHEMBL4862044 | — | — | 1 | 5.42 |
| CHEMBL4873503 | — | — | 1 | 5.24 |
| CHEMBL4847264 | — | — | 1 | 5.11 |
| CHEMBL4846913 | — | — | 1 | 5.02 |
| CHEMBL4860999 | — | — | 1 | 5.00 |
| CHEMBL3787662 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4850239 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL4297865 | ABIVERTINIB | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL4862044 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4873503 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL4847264 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4846913 | — | IC50 | = | 9540.0 | nM | 5.02 |
| CHEMBL4860999 | — | IC50 | = | 9890.0 | nM | 5.00 |
| CHEMBL3787662 | — | IC50 | = | 23800.0 | nM | 4.62 |