Assay Detail
Functional
CHEMBL4829468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.20 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297865 | ABIVERTINIB | 3.0 | 1 | 5.81 |
| CHEMBL4862044 | — | — | 1 | 5.78 |
| CHEMBL4850239 | — | — | 1 | 5.51 |
| CHEMBL4847264 | — | — | 1 | 5.42 |
| CHEMBL4873503 | — | — | 1 | 5.38 |
| CHEMBL3787662 | — | — | 1 | 4.66 |
| CHEMBL4860999 | — | — | 1 | 4.65 |
| CHEMBL4846913 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297865 | ABIVERTINIB | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4862044 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4850239 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4847264 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL4873503 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL3787662 | — | IC50 | = | 21980.0 | nM | 4.66 |
| CHEMBL4860999 | — | IC50 | = | 22430.0 | nM | 4.65 |
| CHEMBL4846913 | — | IC50 | = | 41980.0 | nM | 4.38 |