Assay Detail
Binding
CHEMBL4829486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR L858R mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 mins by mobility shift assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.62 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297865 | ABIVERTINIB | 3.0 | 1 | 9.77 |
| CHEMBL4847264 | — | — | 1 | 9.68 |
| CHEMBL4850239 | — | — | 1 | 9.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297865 | ABIVERTINIB | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL4847264 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL4850239 | — | IC50 | = | 0.39 | nM | 9.41 |